Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $168.30 | Total: $841.50 |
| 1 | 10 | $142.56 | Total: $1,425.60 |
| 1 | 25 | $120.78 | Total: $3,019.50 |
| 1 | 50 | $102.96 | Total: $5,148.00 |
| 1 | 100 | $89.10 | Total: $8,910.00 |
Overview
ART812 is an orally active inhibitor of DNA polymerase Pol?, possessing an IC50 value of 7.6 nM. Additionally, ART812 exhibits a cell-based microhomology-mediated end joining (MMEJ) IC50 value of 240 nM.
Chemical Properties
| Molecular Formula | C19H16ClF4N3O4 |
| Molecular Weight | 461.79 |
| CAS Numbers | 2607138-82-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CN(C(=O)[C@@H]1[C@H](O)[C@H](O)C(=O)N1c1cc(cc(C)n1)C(F)(F)F)c1ccc(F)c(Cl)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zatreanu D, et al. Pol? inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nat Commun. 2021 Jun 17;12[1] 3636.