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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $142.80 | Total: $714.00 |
| 1 | 10 | $120.96 | Total: $1,209.60 |
| 1 | 25 | $102.48 | Total: $2,562.00 |
| 1 | 50 | $87.36 | Total: $4,368.00 |
| 1 | 100 | $75.60 | Total: $7,560.00 |
Overview
RP-6685, a highly potent and selective inhibitor of DNA polymerase theta (Pol?), manifests remarkable oral activity. With an IC 50 value of 5.8 nM in the PicoGreen assay, RP-6685 effectively hinders the enzymatic activity of Pol?. In addition, it demonstrates significant antitumor efficacy as observed in a mouse tumor xenograft model [1].
Chemical Properties
| Molecular Formula | C22H14F7N5O |
| Molecular Weight | 497.37 |
| CAS Numbers | 2832047-80-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Nc1ccc(nn1)C#CCN(C(=O)Cc1ncc(cc1C(F)(F)F)C(F)(F)F)c1ccc(F)cc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Bubenik M, et al. Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Pol?. J Med Chem. 2022 Sep 20.