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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $32.30 | Total: $161.50 |
| 1 | 10 | $27.36 | Total: $273.60 |
| 1 | 25 | $23.18 | Total: $579.50 |
| 1 | 50 | $19.76 | Total: $988.00 |
| 1 | 100 | $17.10 | Total: $1,710.00 |
Overview
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 ?M), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activity exploration suggests that Bractoppin engages BRCA1 tBRCT residues recognizing pSer in the consensus motif, pSer-Pro-Thr-Phe, plus an abutting hydrophobic pocket that is distinct in structurally related BRCT domains, conferring selectivity.
Chemical Properties
| Molecular Formula | C25H23FN4O |
| Molecular Weight | 414.47 |
| CAS Numbers | 2290527-07-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Fc1ccccc1CN1CCN(CC1)C(=O)c1ccc2[nH]c(nc2c1)-c1ccccc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Periasamy J , Kurdekar V , Jasti S , et al. Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling[J]. Cell Chemical Biology, 2018 S245194561830076X.