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Overview
Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule.
Chemical Properties
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.66 |
| CAS Numbers | 133-67-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
Temperini C, et al. Bioorg Med Chem. 2009 Feb 1;17[3] 1214-21.