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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $141.95 | Total: $709.75 |
| 1 | 10 | $120.24 | Total: $1,202.40 |
| 1 | 25 | $101.87 | Total: $2,546.75 |
| 1 | 50 | $86.84 | Total: $4,342.00 |
| 1 | 100 | $75.15 | Total: $7,515.00 |
Overview
FR-167356 is a specific inhibitor of a3 isoform vacuolar type H?-ATPase with IC50s of 170 nM, 370 nM and 220 nM for osteoclast plasma membranes, renal brush border membranes and macrophage microsomes. FR-167356 reduces bone metastasis of B16-F10 cells.
Chemical Properties
| Molecular Formula | C19H17Cl2NO3 |
| Molecular Weight | 378.25 |
| CAS Numbers | 174185-16-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(C)(C)(O)C=1C=2C(=C(NC(=O)C3=C(Cl)C=CC=C3Cl)C=CC2)OC1C |
Storage and Handling
0C Short Term, -20C Long Term
References
Nishisho T, et al. The a3 isoform vacuolar type H?-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9[7] 845-55.