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Overview
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI disorders. It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form. Trimebutine is not an FDA-ApprovedClinical drug, but it is available in Canada and several other international countries.
Chemical Properties
| Molecular Formula | C22H29NO5 |
| Molecular Weight | 387.47 |
| CAS Numbers | 39133-31-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(COC(=O)C1=CC(OC)=C(OC)C(OC)=C1)(N(C)C)(CC)C2=CC=CC=C2 |
Storage and Handling
0C Short Term, -20C Long Term
References
Prescrire Int. 2013 Oct;22[142] 241-2.