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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $89.25 | Total: $446.25 |
| 1 | 10 | $75.60 | Total: $756.00 |
| 1 | 25 | $64.05 | Total: $1,601.25 |
| 1 | 50 | $54.60 | Total: $2,730.00 |
| 1 | 100 | $47.25 | Total: $4,725.00 |
Overview
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Tollinterleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interaction with MyD88. EM 163 inhibits the production of inflammatory cytokines in vivo caused by staphylococcal enterotoxin B (SEB). EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocked the activation of p38 and the inhibitory effect of IL-1? on chemically induced long-term potentiation (LTP)-triggered protein synthesis.
Chemical Properties
| Molecular Formula | C44H60IN5O4 |
| Molecular Weight | 849.88 |
| CAS Numbers | 1206480-93-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N([C@H](C(=O)N1CCCC1)C(C)C)(C(=O)C2=C[N+](C)=C(C(N([C@H](C(=O)N3CCCC3)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)CCCC5=CC=CC=C5.[I-] |
Storage and Handling
0C Short Term, -20C Long Term
References
Prieto GA, et al. Inhibition of LTP-Induced Translation by IL-1? Reduces the Level of Newly Synthesized Proteins in Hippocampal Dendrites. ACS Chem Neurosci. 2019;10[3] 1197-1203.