Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $195.50 | Total: $977.50 |
| 1 | 10 | $165.60 | Total: $1,656.00 |
| 1 | 25 | $140.30 | Total: $3,507.50 |
| 1 | 50 | $119.60 | Total: $5,980.00 |
| 1 | 100 | $103.50 | Total: $10,350.00 |
Overview
Brigimadlin (BI 907828) is an orally active and highly potent E3 ubiquitin-protein ligase MDM2-p53 antagonist with antitumor activity.Brigimadlin can be used to study metastatic BTC, PDAC, lung adenocarcinoma, or bladder cancer.
Chemical Properties
| Molecular Formula | C31H25Cl2FN4O3 |
| Molecular Weight | 591.46 |
| CAS Numbers | 2095116-40-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(N1[C@@]2([C@H]([C@]3([C@@]1(CC=4N3N=C5C4C=CC(C(O)=O)=C5C)[H])[H])C6=C(F)C(Cl)=CC=C6)C=7C(NC2=O)=CC(Cl)=CC7)C8CC8 |
Storage and Handling
0C Short Term, -20C Long Term
References
Yunhui Hu, et Al. Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer. Cancer Lett. 2018 Jun 1 423 47-59.