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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $76.50 | Total: $382.50 |
| 1 | 10 | $64.80 | Total: $648.00 |
| 1 | 25 | $54.90 | Total: $1,372.50 |
| 1 | 50 | $46.80 | Total: $2,340.00 |
| 1 | 100 | $40.50 | Total: $4,050.00 |
Overview
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
Chemical Properties
| Molecular Formula | C24H21ClF2N4O5 |
| Molecular Weight | 518.9 |
| CAS Numbers | 1416663-77-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C(C(NC(CO)CO)=O)(N1C(=O)C(=CC=2C=3C(NC2)=C(C)C(Cl)=CC3)NC1=O)C4=CC(F)=C(F)C=C4 |
Storage and Handling
0C Short Term, -20C Long Term
References
Graves B, et al. Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization. Proc Natl Acad Sci U S A. 2012 Jul 17;109[29] 11788-93.