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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $39.95 | Total: $199.75 |
| 1 | 10 | $33.84 | Total: $338.40 |
| 1 | 25 | $28.67 | Total: $716.75 |
| 1 | 50 | $24.44 | Total: $1,222.00 |
| 1 | 100 | $21.15 | Total: $2,115.00 |
Overview
NCT-58 is a potent C-terminal HSP90 inhibitor. NCT-58 does not induce the heat shock response (HSR). NCT-58 elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.
Chemical Properties
| Molecular Formula | C27H34N2O5 |
| Molecular Weight | 466.57 |
| CAS Numbers | 2411429-33-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1cc(NC(=O)c2ccc3OC(C)(C)C=Cc3c2OC)ccc1OCCC1CCCCN1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Park S, et al. The C-terminal HSP90 inhibitor NCT-58 kills trastuzumab-resistant breast cancer stem-like cells. Cell Death Discov. 2021;7[1] 354.