Baloxavir acid

Name: Baloxavir acid
Brand: AOBIOUS
SKU: AOB17349
Price: 31 USD
Availability: InStock

Cat No: AOB17349

Condition

CAS No: 1985605-59-1

Chemical Name: Baloxavir; BXA; (R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione

AOBIOUS launched this product in 2019

CITATIONS - Publications That Use AOBIOUS Product

1) Nat Commun. 2022; 13: 251

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$26.35	Total: $131.75
1	10	$22.32	Total: $223.20
1	25	$18.91	Total: $472.75
1	50	$16.12	Total: $806.00
1	100	$13.95	Total: $1,395.00

Overview

First-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

Chemical Properties

Molecular Formula	C24H19F2N3O4S
Molecular Weight	483.49
CAS Numbers	1985605-59-1
Solubility	DMSO
Purity	98% by HPLC
IUPAC/Chemical Name	(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione
InChl Key	FIDLLEYNNRGVFR-CTNGQTDRSA-N
InChl Code	InChI=1S/C24H19F2N3O4S/c25-16-6-5-13-15(20(16)26)12-34-18-4-2-1-3-14(18)21(13)29-19-11-33-10-9-27(19)24(32)22-23(31)17(30)7-8-28(22)29/h1-8,19,21,31H,9-12H2/t19-,21+/m1/s1
SMILES Code	O=C1N2[C@](COCC2)([H])N([C@@H]3C4=CC=CC=C4SCC5=C(F)C(F)=CC=C35)N6C1=C(O)C(C=C6)=O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

Baloxavir; Baloxavir acid; BXA

References

1) Koshimichi H, Ishibashi T, Wajima T. Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients. J Pharm Sci. 2019 Apr 15. pii: S0022-3549(19)30236-9.

2) LaVoie EJ, Sagong HY, Bauman JD, Nogales A, Martínez-Sobrido L, Arnold E. Aryl and arylalkyl substituted 3-hydroxypyridin(1H)-2-ones: Synthesis and evaluation as inhibitors of influenza A endonuclease. ChemMedChem. 2019 Apr 14.

3) Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC. Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. Antiviral Res. 2019 Apr 8;167:45-67.