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GSK114
AOB36917
CAS: 1301760-19-9
Chemical Name: 3-[(6,7-Dimethoxy-4-quinazolinyl)amino]-4-(dimethylamino)-N-methyl-benzenesulfonamide dihydrochloride
1989 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $31.87 | Total: $159.37 |
| 1 | 10 | $27.00 | Total: $270.00 |
| 1 | 25 | $22.88 | Total: $571.88 |
| 1 | 50 | $19.50 | Total: $975.00 |
| 1 | 100 | $16.88 | Total: $1,687.50 |
Overview
Novel selective inhibitor for elucidating the biological role of TNNI3K, displaying significant bias (40-fold) for TNNI3K over B-Raf, exceptional broad-spectrum kinase selectivity, and adequate oral exposure to enable its use in cellular and in vivo studies
Chemical Properties
| Molecular Formula | C19H25Cl2N5O4S |
| Molecular Weight | 490.40 |
| CAS Numbers | 1301760-19-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-((6,7-dimethoxyquinazolin-4-yl)amino)-4-(dimethylamino)-N-methylbenzenesulfonamide |
| InChl Key | YUSROMRPOFFTMX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H23N5O4S/c1-20-29(25,26)12-6-7-16(24(2)3)15(8-12)23-19-13-9-17(27-4)18(28-5)10-14(13)21-11-22-19/h6-11,20H,1-5H3,(H,21,22,23) |
| SMILES Code | O=S(C1=CC=C(N(C)C)C(NC2=C3C=C(OC)C(OC)=CC3=NC=N2)=C1)(NC)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
GSK-114; GSK 114; GSK114.
References
Brian G. Lawhorn, Joanne Philp, Alan P. Graves, Lisa Shewchuk, Dennis A. Holt, Gregory J. Gatto Jr., Lara S. Kallander. GSK114: A selective inhibitor for elucidating the biological role of TNNI3K In Press, Accepted Manuscript. 14 May 2016
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