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PQ912
AOB36784
CAS: 1276021-65-8
Chemical Name: 1-(3H-Benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one
901 Items
PQ912 was discontinued for commercial reason.
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $0.00 | Total: $0.00 |
| 1 | 10 | $0.00 | Total: $0.00 |
| 1 | 25 | $0.00 | Total: $0.00 |
| 1 | 50 | $0.00 | Total: $0.00 |
| 1 | 100 | $0.00 | Total: $0.00 |
Overview
Novel Glutaminyl Cyclase (QCPT) Inhibitor, Improving Cognition in Mouse Models of Alzheimer's Disease
Chemical Properties
| Molecular Formula | C19H20N4O2 |
| Molecular Weight | 336.40 |
| CAS Numbers | 1276021-65-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (S)-1-(3H-Benzimidazol-5-yl)-5-(4-propoxyphenyl)imidazolidin-2-one |
| InChl Key | XHIKZWOEFZENIX-GOSISDBHSA-N |
| InChl Code | InChI=1S/C19H20N4O2/c1-2-9-25-15-6-3-13(4-7-15)18-11-20-19(24)23(18)14-5-8-16-17(10-14)22-12-21-16/h3-8,10,12,18H,2,9,11H2,1H3,(H,20,24)(H,21,22)/t18-/m1/s1 |
| SMILES Code | O=C1NC[C@H](C2=CC=C(OCCC)C=C2)N1C3=CC=C4C(NC=N4)=C3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PQ-912; PQ 912; PQ912
References
1) Scheltens P, Hallikainen M, Grimmer T, Duning T, Gouw AA, Teunissen CE, Wink AM, Maruff P, Harrison J, van Baal CM, Bruins S, Lues I, Prins ND. Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer's disease: results of a randomized, double-blind, placebo-controlled phase 2a study. Alzheimers Res Ther. 2018 Oct 12;10(1):107.
2) Pozzi C, Di Pisa F, Benvenuti M, Mangani S. The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders. J Biol Inorg Chem. 2018 Dec;23(8):1219-1226.
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