G140

G140

AOB13353

CAS: 2369751-07-3

 

Chemical Name: 1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one

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$45.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $38.25 Total: $191.25
110 $32.40 Total: $324.00
125 $27.45 Total: $686.25
150 $23.40 Total: $1,170.00
1100 $20.25 Total: $2,025.00

Overview

Novel potent cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 14 nM and 442 nM for h-cGAS and m-cGAS, respectively)













Chemical Properties

Molecular FormulaC17H16Cl2N4O2
Molecular Weight379.24
CAS Numbers2369751-07-3
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Name1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
InChl KeyNVPFAXHXXODQRO-UHFFFAOYSA-N
InChl CodeInChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3
SMILES CodeO=C(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)CO

Storage and Handling

0°C (short term), -20°C (long term), desiccated

References

1) Rhee SY, et al. A systematic review of the genetic mechanisms of dolutegravir resistance. J Antimicrob Chemother. 2019 Nov 1;74(11):3135-3149. doi: 10.1093/jac/dkz256. PubMed PMID: 31280314; PubMed Central PMCID: PMC6798839.

2) Ferrari D, et al. Increased dose of dolutegravir as a potential rescue therapy in multi-experienced patients. Antivir Ther. 2019;24(1):69-72.

3) Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157

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