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LGH447
AOB37522
CAS: 1210608-43-7
Chemical Name: PIM447; N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide
2963 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $42.08 | Total: $210.38 |
| 1 | 10 | $35.64 | Total: $356.40 |
| 1 | 25 | $30.20 | Total: $754.88 |
| 1 | 50 | $25.74 | Total: $1,287.00 |
| 1 | 100 | $22.28 | Total: $2,227.50 |
Overview
Potent and specific pan-PIM inhibitor, inhibiting proliferation of several AML cell lines, showing dual antitumoral and bone antiresorptive effects
Chemical Properties
| Molecular Formula | C24H23F3N4O |
| Molecular Weight | 440.47 |
| CAS Numbers | 1210608-43-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide |
| InChl Key | VRQXRVAKPDCRCI-ZNMIVQPWSA-N |
| InChl Code | InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1 |
| SMILES Code | O=C(NC1=C([C@H]2C[C@@H](N)C[C@@H](C)C2)C=CN=C1)C3=NC(C4=C(F)C=CC=C4F)=C(F)C=C3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
LGH-447; LGH 447; LGH447; PIM447; PIM-447; PIM 447; LGH447 free base
References
1) Paíno T et al. The novel pan-PIM kinase inhibitor, PIM447, displays dual anti-myeloma and bone protective effects, and potently synergizes with current standards of care. Clin Cancer Res. 2016 Jul 20.
2) Peters TL et al. Control of translational activation by PIM kinase in activated B-cell diffuse large B-cell lymphoma confers sensitivity to inhibition by PIM447. Oncotarget. 2016 Aug 20
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