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Pralsetinib (BLU667)
AOB17991
CAS: 2097132-94-8
Chemical Name: BLU667; (1s,4R)-N-((S)-1-(6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethyl)-1-methoxy-4-(4-methyl-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide
99 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.95 | Total: $114.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 100 | $12.15 | Total: $1,215.00 |
Overview
Novel highly potent and selective inhibitor of oncogenic RET fusion, inhibiting Wt RET, RET mutants V804L, V804M, M918T, and CCDC6-RET fusion, displaying broad and robust anti-tumor activity against multiple RET-driven solid tumor types
Chemical Properties
| Molecular Formula | C36H40Cl2N4O8 |
| Molecular Weight | 727.64 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | cis-N-{(1S)-1-[6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}-1-methoxy-4-{4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl}cyclohexane-1-carboxamide |
| InChl Key | MXSCYXULRDBMTH-RWYJCYHVSA-N |
| InChl Code | InChI=1S/C27H32FN9O2/c1-16-11-23(33-25(32-16)19-7-9-27(39-4,10-8-19)26(29)38)37(24-12-17(2)34-35-24)18(3)20-5-6-22(30-13-20)36-15-21(28)14-31-36/h5-6,11-15,18-19H,7-10H2,1-4H3,(H2,29,38)(H,34,35)/t18-,19-,27+/m0/s1 |
| SMILES Code | O=C([C@@]1(OC)CC[C@@H](C2=NC(NC3=NNC(C)=C3)=CC(C)=N2)CC1)N[C@H](C4=CC=C(N5N=CC(F)=C5)N=C4)C |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Pralsetinib; BLU-667; BLU 667; BLU667
References
1) Subbiah V, et al. Precision Targeted Therapy With BLU-667 for RET-Driven Cancers. American Association for Cancer Research. 10.1158/2159-8290.CD-18-0338.
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