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Odevixibat
AOB17223
CAS: 501692-44-0
Chemical Name: A4250; (2S)-2-[[(2R)-[[[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino](4-hydroxyphenyl)acetyl]amino]-butanoic acid
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $38.25 | Total: $191.25 |
| 1 | 10 | $32.40 | Total: $324.00 |
| 1 | 25 | $27.45 | Total: $686.25 |
| 1 | 50 | $23.40 | Total: $1,170.00 |
| 1 | 100 | $20.25 | Total: $2,025.00 |
Overview
Novel inhibitor of ileal bile acid transporter (IBAT); also called apical sodium-dependent bile acid transporter
Chemical Properties
| Molecular Formula | C37H48N4O8S2 |
| Molecular Weight | 740.93 |
| CAS Numbers | 501692-44-0 |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (S)-2-((R)-2-(2-((3,3-dibutyl-7-(methylthio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydrobenzo[f][1,2,5]thiadiazepin-8-yl)oxy)acetamido)-2-(4-hydroxyphenyl)acetamido)butanoic acid |
| InChl Key | XULSCZPZVQIMFM-IPZQJPLYSA-N |
| InChl Code | InChI=1S/C37H48N4O8S2/c1-5-8-19-37(20-9-6-2)24-41(26-13-11-10-12-14-26)29-21-31(50-4)30(22-32(29)51(47,48)40-37)49-23-33(43)39-34(25-15-17-27(42)18-16-25)35(44)38-28(7-3)36(45)46/h10-18,21-22,28,34,40,42H,5-9,19-20,23-24H2,1-4H3,(H,38,44)(H,39,43)(H,45,46)/t28-,34+/m0/s1 |
| SMILES Code | CC[C@H](NC([C@H](NC(COC1=C(SC)C=C(C2=C1)N(C3=CC=CC=C3)CC(CCCC)(CCCC)NS2(=O)=O)=O)C4=CC=C(O)C=C4)=O)C(O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
AZD 8294; AZD8294; AZD-8294; A-4250; A4250; A 4250; AR-H 064974; AR-H064974; AR-H-064974; Odevixibat
References
1) Saveleva EE, Tyutrina ES, Nakanishi T, Tamai I, Salmina AB. Ingibitory natriĭ-zavisimogo perenoschika zhelchnykh kislot (ASBT) kak perspektivnye lekarstvennye sredstva [The inhibitors of the apical sodium-dependent bile acid transporter (ASBT) as promising drugs]. Biomed Khim. 2020 May;66(3):185-195. Russian. doi: 10.18097/PBMC20206603185. PMID: 32588824.
2) Al-Dury S, Wahlström A, Wahlin S, Langedijk J, Elferink RO, Ståhlman M, Marschall HU. Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis. Sci Rep. 2018 Apr 27;8(1):6658. doi: 10.1038/s41598-018-25214-0. PMID: 29704003; PMCID: PMC5923243.