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Actinomycin D
AOB9952
CAS: 50-76-0
Chemical Name: Dactinomycin; Actinomycin I; Oncostatin K; Chounghwamycin B; 2-Amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide
998 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $22.95 | Total: $114.75 |
| 1 | 10 | $19.44 | Total: $194.40 |
| 1 | 25 | $16.47 | Total: $411.75 |
| 1 | 50 | $14.04 | Total: $702.00 |
| 1 | 100 | $12.15 | Total: $1,215.00 |
Overview
Inhibitor of RNA synthesis (transcription), binding to DNA and impairing mRNA production
Chemical Properties
| Molecular Formula | C62H86N12O16 |
| Molecular Weight | 1255.5 |
| CAS Numbers | 50-76-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 2-amino-N,N'-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide |
| InChl Key | RJURFGZVJUQBHK-DCUCITLNSA-N |
| InChl Code | nChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70 |
| SMILES Code | CC1=C2C(C(C(N[C@H](C(N[C@@H](C(C)C)C(N3[C@@](C(N(C)CC4=O)=O)([H])CCC3)=O)=O)[C@@H](C)OC([C@H](C(C)C)N4C)=O)=O)=C(N)C1=O)=NC5=C(C(N[C@@H]([C@@H](C)OC([C@H](C(C)C)N(C)C(CN(C([C@]6([H])CCCN6C([C@H](C(C)C)N7)=O)=O)C)=O)=O)C7=O)=O)C=CC(C)=C5O2 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Cosmegen, Dactinomycin, Meractinomycin, NCI C04682, NSC 3053
References
1) Paramanathan, T., Vladescu, I., McCauley, M.J., et al. Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D. Nucleic Acids Research 40(11), 4925-4932 (2012).
2) Sobell, H.M. Actinomycin and DNA transcription. Proceedings of the National Academy of Sciences of the United States of America 82, 5328-5331 (1985).
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