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3i-1000
AOB13280
CAS: 544681-96-1
Chemical Name: GATA4/NKX2-5 Modulator-3; N-[4-(Diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamid
57 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $31.45 | Total: $157.25 |
| 1 | 10 | $26.64 | Total: $266.40 |
| 1 | 25 | $22.57 | Total: $564.25 |
| 1 | 50 | $19.24 | Total: $962.00 |
| 1 | 100 | $16.65 | Total: $1,665.00 |
Overview
Novel potent inhibitor of GATA4-NKX2-5 interaction, significantly reducing mechanical stretch induced hypertrophic growth reflected by an increase in cardiomyocyte cell size and ANP and BNP mRNA levels in response to mechanical stretch
Chemical Properties
| Molecular Formula | C21H23N3O2 |
| Molecular Weight | 349.43 |
| CAS Numbers | 544681-96-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-[4-(Diethylamino)phenyl]-5-methyl-3-phenylisoxazole-4-carboxamide |
| InChl Key | UDDOZWWBHVIGDS-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H23N3O2/c1-4-24(5-2)18-13-11-17(12-14-18)22-21(25)19-15(3)26-23-20(19)16-9-7-6-8-10-16/h6-14H,4-5H2,1-3H3,(H,22,25) |
| SMILES Code | O=C(C1=C(C)ON=C1C2=CC=CC=C2)NC3=CC=C(N(CC)CC)C=C3 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
3i-1000; 3i 1000; 3i1000; GATA4-NKX2-5-IN-1
References
1) Sini M. Kinnunen et al., Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction, Scientific Reports volume 8, Article number: 4611 (2018)
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