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K-975
AOB11890
CAS: 2563855-03-6
Chemical Name: N-(3-(4-Chlorophenoxy)-4-methylphenyl)acrylamide
1996 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $14.45 | Total: $72.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 100 | $7.65 | Total: $765.00 |
Overview
First-in-class TEAD inhibitor, directly inhibiting YAP/TAZ-TEAD protein-protein interaction and showing a potent anti-tumor effect in malignant pleural mesothelioma
Chemical Properties
| Molecular Formula | C16H14ClNO2 |
| Molecular Weight | 287.74 |
| CAS Numbers | 2563855-03-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-(3-(4-chlorophenoxy)-4-methylphenyl)acrylamide |
| InChl Key | KPXAHQSIROUBPH-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C16H14ClNO2/c1-3-16(19)18-13-7-4-11(2)15(10-13)20-14-8-5-12(17)6-9-14/h3-10H,1H2,2H3,(H,18,19) |
| SMILES Code | C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
K-975; K975; K 975;
References
1) 1. Kaneda A, Seike T, Danjo T, Nakajima T, Otsubo N, Yamaguchi D, Tsuji Y, Hamaguchi K, Yasunaga M, Nishiya Y, Suzuki M, Saito JI, Yatsunami R, Nakamura S, Sekido Y, Mori K. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415. PMID: 33415007; PMCID: PMC7783735.
2) Lee S, Chung G, Kim J, Oh HB. Electron capture dissociation mass spectrometry of peptide cations containing a lysine homologue: a mobile proton model for explaining the observation of b-type product ions. Rapid Commun Mass Spectrom. 2006;20(21):3167-75. doi: 10.1002/rcm.2708. PMID: 17016809.