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SHIN2
AOB11286
CAS: 2204289-53-0
Chemical Name: 6-Amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
AOBIOUS launched this product in 2018
CITATIONS - Publications That Use AOBIOUS Product
714 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $38.25 | Total: $191.25 |
| 1 | 10 | $32.40 | Total: $324.00 |
| 1 | 25 | $27.45 | Total: $686.25 |
| 1 | 50 | $23.40 | Total: $1,170.00 |
| 1 | 100 | $20.25 | Total: $2,025.00 |
Overview
Novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo
Chemical Properties
| Molecular Formula | C23H26N4O3 |
| Molecular Weight | 406.49 |
| CAS Numbers | 2204289-53-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 6-Amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
SHIN 2, SHIN-2
References
1) Juan C. García-Cañaveras et. eal., SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia, Leukemia volume 35, pages377–388 (2021)
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