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Vebicorvir
AOB14476
CAS: 2090064-66-5
Chemical Name: ABI-H0731; 11-Oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide-5,5-dioxide
500 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $126.65 | Total: $633.25 |
| 1 | 10 | $107.28 | Total: $1,072.80 |
| 1 | 25 | $90.89 | Total: $2,272.25 |
| 1 | 50 | $77.48 | Total: $3,874.00 |
| 1 | 100 | $67.05 | Total: $6,705.00 |
Overview
First-generation hepatitis B virus (HBV) core protein inhibitor
Chemical Properties
| Molecular Formula | C22H20F2N4O2 |
| Molecular Weight | 410.43 |
| CAS Numbers | 1369764-02-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 11-oxo-N-((2-(trifluoromethyl)thiazol-5-yl)methyl)-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide |
| InChl Key | LBJVBJYMZKEREY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H12F3N3O4S2/c20-19(21,22)18-24-9-11(30-18)8-23-16(26)10-5-6-15-13(7-10)25-17(27)12-3-1-2-4-14(12)31(15,28)29/h1-7,9H,8H2,(H,23,26)(H,25,27) |
| SMILES Code | O=C(NCC1=CN=C(C(F)(F)F)S1)C(C=C2)=CC3=C2S(C4=CC=CC=C4C(N3)=O)(=O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Vebicorvir; ABI H0731; ABI-H0731; ABIH0731; ABIH 0731; ABIH-0731; ABI H 0731; ABI H-0731;
References
1) Huang Q, Cai D, Yan R, Li L, Zong Y, Guo L, Mercier A, Zhou Y, Tang A, Henne K, Colonno R. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20. doi: 10.1128/AAC.01463-20. PMID: 32868329.
2) Smolders EJ, Burger DM, Feld JJ, Kiser JJ. Review article: clinical pharmacology of current and investigational hepatitis B virus therapies. Aliment Pharmacol Ther. 2020 Jan;51(2):231-243. doi: 10.1111/apt.15581. Epub 2019 Dec 16. PMID: 31840863.