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DCH36_06
AOB17776
CAS: 593273-05-3
Chemical Name: 1-(3-Chloro-4-methylphenyl)-5-(3-(furan-2-yl)allylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
100 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity (mg or Unit) | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|
| 5 | $67.15 | Total: $335.75 |
| 10 | $56.88 | Total: $568.80 |
| 25 | $48.19 | Total: $1,204.75 |
| 50 | $41.08 | Total: $2,054.00 |
| 100 | $35.55 | Total: $3,555.00 |
Overview
Novel potent p300/CBP inhibitor, showing potent anti-proliferation as well as anti-tumor activity in leukemia xenograft
Chemical Properties
| Molecular Formula | C18H13ClN2O3S |
| Molecular Weight | 372.82 |
| CAS Numbers | 593273-05-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 1-(3-Chloro-4-methylphenyl)-5-(3-(furan-2-yl)allylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione |
| InChl Key | AYNCXNUUERDREH-FMDPHQNASA-N |
| InChl Code | InChI=1S/C18H13ClN2O3S/c1-11-7-8-12(10-15(11)19)21-17(23)14(16(22)20-18(21)25)6-2-4-13-5-3-9-24-13/h2-10H,1H3,(H,20,22,25)/b4-2+,14-6+ |
| SMILES Code | O=C(/C(C(N1C2=CC=C(C)C(Cl)=C2)=O)=CC=CC3=CC=CO3)NC1=S |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
DCH36_06; DCH36 06; DCH36-06; DCH 36-06; DCH36-06; DCH-36-06; DCH 3606; DCH-3606; DCH3606;
References
1) Lu W, Xiong H, Chen Y, Wang C, Zhang H, Xu P, Han J, Xiao S, Ding H, Chen Z, Lu T, Wang J, Zhang Y, Yue L, Liu YC, Zhang C, Yang Y, Jiang H, Chen K, Zhou B, Luo C. Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors. Bioorg Med Chem. 2018 Nov 1;26(20):5397-5407. doi: 10.1016/j.bmc.2018.07.048. Epub 2018 Jul 27. PubMed PMID: 30297119.