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Brincidofovir
AOB37050
CAS 444805-28-1
Chemical Name: P-[[(1S)-2-
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $14.87 | Total: $74.37 |
| 1 | 10 | $12.60 | Total: $126.00 |
| 1 | 25 | $10.68 | Total: $266.88 |
| 1 | 50 | $9.10 | Total: $455.00 |
| 1 | 100 | $7.88 | Total: $787.50 |
Overview
Prodrug of cidofovir for the treatment of Ebola virus disease
Chemical Properties
| Molecular Formula | C27H52N3O7P |
| Molecular Weight | 561.7 |
| CAS Numbers | 444805-28-1 |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | P-[[(1S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]-phosphonic acid, mono[3-(hexadecyloxy)propyl] ester |
| InChl Key | WXJFKKQWPMNTIM-VWLOTQADSA-N |
| InChl Code | InChI=1S/C27H52N3O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19-35-20-16-21-37-38(33,34)24-36-25(23-31)22-30-18-17-26(28)29-27(30)32/h17-18,25,31H,2-16,19-24H2,1H3,(H,33,34)(H2,28,29,32)/t25-/m0/s1 |
| SMILES Code | O=P(OCCCOCCCCCCCCCCCCCCCC)(O)CO[C@H](CO)CN1C(N=C(C=C1)N)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Hexadecyloxypropyl-CDV; 1-O-hexadecyloxypropyl Cidofovir; CMX001; HDP-CDV; HDP (S)-HPMPC
References
1) Aldern, K.A., Ciesla, S.L., Winegarden, K.L., et al. Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-14C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism. Mol. Pharmacol. 63(3), 678-681 (2003).
2) Quenelle, D.C., Collins, D.J., Wan, W.B., et al. Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir. Antimicrob. Agents Chemother. 48(2), 404-412 (2004).