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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $64.60 | Total: $323.00 |
| 1 | 10 | $54.72 | Total: $547.20 |
| 1 | 25 | $46.36 | Total: $1,159.00 |
| 1 | 50 | $39.52 | Total: $1,976.00 |
| 1 | 100 | $34.20 | Total: $3,420.00 |
Overview
Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-?-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt?-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of ?-catenin in mouse L cells (IC50=50 nM).
Chemical Properties
| Molecular Formula | C83H114N18O23S2 |
| Molecular Weight | 1796.03 |
| CAS Numbers | 2247635-23-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C([C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CC(C)C)NC(C)=O)=O)CCC2)CO)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCSC)=O)[C@H](C)C)=O)=O)CS)=O)C=5C=6C(NC5)=CC=CC6 |
Storage and Handling
0C Short Term, -20C Long Term
References
Nile AH, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14[9] 902.