Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
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- Molecular Probes
- Stem Cell Research
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- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
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- Antioxidant
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- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $48.45 | Total: $242.25 |
| 1 | 10 | $41.04 | Total: $410.40 |
| 1 | 25 | $34.77 | Total: $869.25 |
| 1 | 50 | $29.64 | Total: $1,482.00 |
| 1 | 100 | $25.65 | Total: $2,565.00 |
Overview
NRX-103094 is a potent enhancer of the interaction between ?-catenin and the homologous E3 ligase SCF?-TrCP, increasing the affinity of pSer33Ser37 ?-catenin for ?-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
Chemical Properties
| Molecular Formula | C20H11Cl2F3N2O4S |
| Molecular Weight | 503.28 |
| CAS Numbers | 2763260-36-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | S(C1=C(C(NC2=CC(C(O)=O)=CC=C2)=O)C(=O)NC(C(F)(F)F)=C1)C3=C(Cl)C=CC=C3Cl |
Storage and Handling
0C Short Term, -20C Long Term
References
Kyle R Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10[1] 1402.