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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $68.85 | Total: $344.25 |
| 1 | 10 | $58.32 | Total: $583.20 |
| 1 | 25 | $49.41 | Total: $1,235.25 |
| 1 | 50 | $42.12 | Total: $2,106.00 |
| 1 | 100 | $36.45 | Total: $3,645.00 |
Overview
SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
Chemical Properties
| Molecular Formula | C21H21ClN2O |
| Molecular Weight | 352.86 |
| CAS Numbers | 117796-52-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(C)=O)CC4)=CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Conformational considerations in the design of dual antagonists of platelet-activating factor [PAF] and histamine. Bioorg Med Chem. 1999 Jul;7[7] 1413-23. PubMed PMID 10465415.