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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $78.20 | Total: $391.00 |
| 1 | 10 | $66.24 | Total: $662.40 |
| 1 | 25 | $56.12 | Total: $1,403.00 |
| 1 | 50 | $47.84 | Total: $2,392.00 |
| 1 | 100 | $41.40 | Total: $4,140.00 |
Overview
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 ?M. Additionally, TNIK-IN-3 demonstrates inhibitory activity against Flt4 (IC50 = 0.030 ?M), Flt1 (IC50 = 0.191 ?M), and DRAK1 (IC50 = 0.411 ?M). This compound holds potential for carrying out research on colorectal cancer (CRC) [1].
Chemical Properties
| Molecular Formula | C23H18FN3O2 |
| Molecular Weight | 387.41 |
| CAS Numbers | 2754265-25-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Fc1ccc(CN2CCOc3cc(ccc3C2=O)-c2cnc3[nH]ccc3c2)cc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Li Y, et, al. Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5[2 H]-one Derivatives as a New Class of Selective TNIK Inhibitors and Evaluation of Their Anti-Colorectal Cancer Effects. J Med Chem. 2022 Jan 5.