VX-765 (Belnacasan)

Name: VX-765 (Belnacasan)
Brand: AOBIOUS
SKU: AOB87376
Price: 19 USD
Availability: InStock

Cat No: AOB87376

Condition

CAS: 273404-37-8

Chemical Name: Belnacasan; (2S)-1-[(2S)-2-[(4-Amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide

More details

986 Item Items

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$16.15	Total: $80.75
1	10	$13.68	Total: $136.80
1	25	$11.59	Total: $289.75
1	50	$9.88	Total: $494.00
1	100	$8.55	Total: $855.00

Overview

A novel Caspase-1 inhibitor being investigated for the treatment of epilepsy

Chemical Properties

Molecular Formula	C24H33ClN4O6
Molecular Weight	508.99
CAS Numbers	273404-37-8
Solubility	DMSO
Purity	99% (HPLC)
IUPAC/Chemical Name	(S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)-N-((2R,3S)-2-ethoxy-5-oxotetrahydrofuran-3-yl)pyrrolidine-2-carboxamide
InChl Key	SJDDOCKBXFJEJB-MOKWFATOSA-N
InChl Code	InChI=1S/C24H33ClN4O6/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)/t16-,17-,19+,23+/m0/s1
SMILES Code	O=C([C@H]1N(C([C@@H](NC(C2=CC=C(N)C(Cl)=C2)=O)C(C)(C)C)=O)CCC1)N[C@@H](C3)[C@H](OCC)OC3=O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

VX 765, VX765, VX-765, Belnacasan

References

1) Noe FM, Polascheck N, Frigerio F, Bankstahl M, Ravizza T, Marchini S, Beltrame L, BanderÃ³ CR, LÃ¶scher W, Vezzani A. Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis. 2013 Nov;59:183-93.

2) Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res. 2013 Jan;103(1):2-30.