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F5446
AOB17639
CAS: 2304465-89-0
Chemical Name: 1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxo-3,4,5,6-tetrahydropyrrolo[3,2-e]indole-1,7-dicarboxylate
AOBIOUS launched this product in 2020
CITATIONS - Publications That Use AOBIOUS Product
57 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $50.15 | Total: $250.75 |
| 1 | 10 | $42.48 | Total: $424.80 |
| 1 | 25 | $35.99 | Total: $899.75 |
| 1 | 50 | $30.68 | Total: $1,534.00 |
| 1 | 100 | $26.55 | Total: $2,655.00 |
Overview
Novel inhibitor of the H3K9me3-specific histone methyltransferase SUV39H1
Chemical Properties
| Molecular Formula | C26H17ClN2O8S |
| Molecular Weight | 552.94 |
| CAS Numbers | 2304465-89-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 1-Benzyl 7-methyl 6-((4-chlorophenyl)sulfonyl)-4,5-dioxo-3,4,5,6-tetrahydropyrrolo[3,2-e]indole-1,7-dicarboxylate |
| InChl Key | MLPQCOLPRPRADV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C26H17ClN2O8S/c1-36-26(33)19-11-17-20-18(25(32)37-13-14-5-3-2-4-6-14)12-28-21(20)23(30)24(31)22(17)29(19)38(34,35)16-9-7-15(27)8-10-16/h2-12,28H,13H2,1H3 |
| SMILES Code | O=C(C1=CNC2=C1C3=C(N(S(=O)(C4=CC=C(Cl)C=C4)=O)C(C(OC)=O)=C3)C(C2=O)=O)OCC5=CC=CC=C5 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
F5446; F 5446; F-5446
References
1) Lu C, et al. SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth. Cancer Lett. 2020 Apr 28;476:87-96. doi: 10.1016/j.canlet.2020.02.004. Epub 2020 Feb 12. PMID: 32061753; PMCID: PMC7138631.
2) Lu C, et al. SUV39H1 Represses the Expression of Cytotoxic T-Lymphocyte Effector Genes to Promote Colon Tumor Immune Evasion. Cancer Immunol Res. 2019 Mar;7(3):414-427. doi: 10.1158/2326-6066.CIR-18-0126. Epub 2019 Jan 4. PMID: 30610059; PMCID: PMC6397681.
