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Aloisine (RP-106)
AOB5673
CAS No:496864-15-4
Chemical Name: Aloisine RP106; 7-Butyl-6-(4-methoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazine
500 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $17.85 | Total: $89.25 |
| 1 | 10 | $15.12 | Total: $151.20 |
| 1 | 25 | $12.81 | Total: $320.25 |
| 1 | 50 | $10.92 | Total: $546.00 |
| 1 | 100 | $9.45 | Total: $945.00 |
Overview
Selective, potent, ATP-competitive inhibitor of CDK1/cyclin B, CDK5/p25, and GSK-3
Chemical Properties
| Molecular Formula | C17H19N3O |
| Molecular Weight | 281.35 |
| CAS Numbers | 496864-15-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine |
| InChl Key | WVMANZPBOBRWCB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H19N3O/c1-3-4-5-14-15(12-6-8-13(21-2)9-7-12)20-17-16(14)18-10-11-19-17/h6-11H,3-5H2,1-2H3,(H,19,20) |
| SMILES Code | COC(C=C1)=CC=C1C2=C(CCCC)C3=NC=CN=C3N2 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
References
1) Mettey, Y., Gompel, M., Thomas, V., et al. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. J. Med. Chem. 46(2), 222-236 (2003).