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Polyoxin B
AOB9353
CAS No: 19396-06-6
Chemical Name: (2S)-2-[[(2S,3S,4S)-2-Amino-5-carbamoyloxy-3,4-dihydroxypentanoyl]amino]-2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]acetic acid
AOBIOUS launched this product in 2016
CITATIONS - Publications That Use AOBIOUS Product
1806 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $12.75 | Total: $63.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 100 | $6.75 | Total: $675.00 |
Overview
Competitive inhibitor of chitin synthetase
Chemical Properties
| Molecular Formula | C17H25N5O13 |
| Molecular Weight | 507.41 |
| CAS Numbers | 19396-06-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (2S)-2-[[(2S,3S,4S)-2-Amino-5-carbamoyloxy-3,4-dihydroxypentanoyl]amino]-2-[(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]acetic acid |
| InChl Key | YFZNSPMAOIVQRP-YVKGXWRCSA-N |
| InChl Code | InChI=1S/C17H25N5O13/c18-6(8(25)5(24)3-34-16(19)32)13(29)20-7(15(30)31)11-9(26)10(27)14(35-11)22-1-4(2-23)12(28)21-17(22)33/h1,5-11,14,23-27H,2-3,18H2,(H2,19,32)(H,20,29)(H,30,31)(H,21,28,33)/t5-,6-,7-,8+,9-,10+,11+,14+/m0/s1 |
| SMILES Code | O=C(O)[C@@H](NC([C@@H](N)[C@H](O)[C@@H](O)COC(N)=O)=O)[C@H]1O[C@@H](N(C(N2)=O)C=C(CO)C2=O)[C@H](O)[C@@H]1O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
Polyoxin B; Polyoxin-B
References
1) Ji Q, Ge Z, Ge Z, Chen K, Wu H, Liu X, Huang Y, Yuan L, Yang X, Liao F. Synthesis and biological evaluation of novel phosphoramidate derivatives of coumarin as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2016 Jan 27;108:166-176
2) Ji Q, etc. Design, synthesis and evaluation of novel quinazoline-2,4-dione derivatives as chitin synthase inhibitors and antifungal agents. Bioorg Med Chem. 2014 Jul 1;22(13):3405-13
3) Yoon MY, etc. Potent in vivo antifungal activity against powdery mildews of pregnane glycosides from the roots of Cynanchum wilfordii. J Agric Food Chem. 2011 Nov 23;59(22):12210-6
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