Categories
- PROTAC Linker
- Protein Control Ligand
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $39.95 | Total: $199.75 |
| 1 | 10 | $33.84 | Total: $338.40 |
| 1 | 25 | $28.67 | Total: $716.75 |
| 1 | 50 | $24.44 | Total: $1,222.00 |
| 1 | 100 | $21.15 | Total: $2,115.00 |
Overview
Ralinepag (APD811) is a potent, orally bioavailable agonist of non-prostanoid prostacyclin (IP) receptor, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
Chemical Properties
| Molecular Formula | C23H26ClNO5 |
| Molecular Weight | 431.91 |
| CAS Numbers | 1187856-49-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Tran TA, et al. Discovery of 2-[[[1r,4r]-4-[[[4-Chlorophenyl][phenyl]carbamoyl]oxy]methyl]cyclohexyl]methoxy]acetate [Ralinepag] An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2017 Feb 9;60[3] 913-927