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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $94.35 | Total: $471.75 |
| 1 | 10 | $79.92 | Total: $799.20 |
| 1 | 25 | $67.71 | Total: $1,692.75 |
| 1 | 50 | $57.72 | Total: $2,886.00 |
| 1 | 100 | $49.95 | Total: $4,995.00 |
Overview
dBRD9 is a PROTAC. dBRD9 is a double-acting molecule, partially containing Bromodomain-containing protein 9 (BRD9), ligand that recruits the cereblon E3 ubiquitin ligase. Ligand that recruits the cereblon E3 ubiquitin ligase. dBRD9 can inhibit the degradation of BRD9 in MOLM-13 cells, and the IC50 is 104 nM.
Chemical Properties
| Molecular Formula | C40H45N7O10 |
| Molecular Weight | 783.83 |
| CAS Numbers | 2170679-45-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCOCCOCCNC(CN(CC4=C(OC)C=C(C=C4OC)C=5C=6C(C(=O)N(C)C5)=CN=CC6)C)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Remillard D, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands. Angew Chem Int Ed Engl. 2017;56[21] 5738-5743.