Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
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Overview
Boc-NH-C4-acid is a PROTAC linker of the Alkylether class, utilized in the synthesis of PROTAC1 for the degradation of EED, EZH2, and SUZ12 in [PRC2].
Chemical Properties
| Molecular Formula | C10H19NO4 |
| Molecular Weight | 217.26 |
| CAS Numbers | 27219-07-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O(C(NCCCCC(O)=O)=O)C(C)(C)C |
Storage and Handling
0C Short Term, -20C Long Term
References
Hsu JH, et al. EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex. Cell Chem Biol. 2019 Nov 26. pii S2451-9456[19]30362-9.