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Overview
(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.
Chemical Properties
| Molecular Formula | C26H41N3O5 |
| Molecular Weight | 475.62 |
| CAS Numbers | 1211877-36-9 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(C)C[C@@H](CC=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Mroczkiewicz M, et al. Studies of the synthesis of all stereoisomers of MG-132 proteasome inhibitors in the tumor targeting approach. J Med Chem. 2010 Feb 25;53[4] 1509-18.