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TG53
AOB2643
CAS No: 946369-04-6
Chemical Name: 5-Chloro-N-[4-[[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino]phenyl]-2-methoxy-benzamide
489 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $50.15 | Total: $250.75 |
| 1 | 10 | $42.48 | Total: $424.80 |
| 1 | 25 | $35.99 | Total: $899.75 |
| 1 | 50 | $30.68 | Total: $1,534.00 |
| 1 | 100 | $26.55 | Total: $2,655.00 |
Overview
Novel inhibitor of tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction
Chemical Properties
| Molecular Formula | C21H22ClN5O2 |
| Molecular Weight | 411.88 |
| CAS Numbers | 946369-04-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 5-Chloro-N-[4-[[4-(dimethylamino)-6-methyl-2-pyrimidinyl]amino]phenyl]-2-methoxy-benzamide |
| InChl Key | JHHHSGYKBKIUBG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C21H22ClN5O2/c1-13-11-19(27(2)3)26-21(23-13)25-16-8-6-15(7-9-16)24-20(28)17-12-14(22)5-10-18(17)29-4/h5-12H,1-4H3,(H,24,28)(H,23,25,26) |
| SMILES Code | O=C(NC1=CC=C(NC2=NC(C)=CC(N(C)C)=N2)C=C1)C3=CC(Cl)=CC=C3OC |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
TG53; TG-53; TG 53;
References
1) Yakubov B, Chen L, Belkin AM, Zhang S, Chelladurai B, Zhang ZY, Matei D. Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction. PLoS One. 2014 Feb 20;9(2):e89285. doi: 10.1371/journal.pone.0089285. eCollection 2014. PubMed PMID: 24586660; PubMed Central PMCID: PMC3930694.
2) Herrera VL, Ponce LR, Ruiz-Opazo N. Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats. J Hypertens. 2007 Aug;25(8):1608-12. PubMed PMID: 17620956.
