PCLX-001 (DDD86481)

Name: PCLX-001 (DDD86481)
Brand: AOBIOUS
SKU: AOB13563
Price: 79 USD
Availability: InStock

Cat No: AOB13563

Condition

CAS: 1215011-08-7

Chemical Name: 2,6-Dichloro-N-(3-isobutyl-1,5-dimethyl-1H-pyrazol-4-yl)-4-(2-(piperazin-1-yl)pyridin-4-yl)benzenesulfonamide

AOBIOUS launched this product in 2021

CITATIONS - Publications That Use AOBIOUS Product

1) The Journal of Biological Chemistry, 30 May 2025, 301(7)

More details

991 Item Items

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Quantity Discount Table - Order More To Get More Price Discount

Quantity	mg	Unit Price ($/mg or $/Unit)	Final Price
1	5	$67.15	Total: $335.75
1	10	$56.88	Total: $568.80
1	25	$48.19	Total: $1,204.75
1	50	$41.08	Total: $2,054.00
1	100	$35.55	Total: $3,555.00

Overview

Novel potent AfNMT inhibitor, potently inhibiting the NMT mutant and being fungicidal under repressed nmt expression

Chemical Properties

Molecular Formula	C23H28Cl2N6O2S
Molecular Weight	523.48
CAS Numbers	1215011-08-7
Solubility	DMSO and Alcohol
Purity	98% by HPLC
IUPAC/Chemical Name	2,6-dichloro-N-(3-isopropyl-1,5-dimethyl-1H-pyrazol-4-yl)-4-(2-(piperazin-1-yl)pyridin-4-yl)benzenesulfonamide
InChl Key	CHDKOQZIUHMUER-UHFFFAOYSA-N
InChl Code	InChI=1S/C23H28Cl2N6O2S/c1-14(2)21-22(15(3)30(4)28-21)29-34(32,33)23-18(24)11-17(12-19(23)25)16-5-6-27-20(13-16)31-9-7-26-8-10-31/h5-6,11-14,26,29H,7-10H2,1-4H3
SMILES Code	CC(C)C1=NN(C)C(C)=C1NS(C2=C(Cl)C=C(C3=CC=NC(N4CCNCC4)=C3)C=C2Cl)(=O)=O

Storage and Handling

0°C (short term), -20°C (long term), desiccated

Synonyms

PCLX-001, PCLX001, PCLX 001, DDD86481; DDD 86481; DDD-86481

References

1) Liu N, Tu J, Dong G, Wang Y, Sheng C. Emerging New Targets for the Treatment of Resistant Fungal Infections. J Med Chem. 2018 Jan 16. doi: 10.1021/acs.jmedchem.7b01413. [Epub ahead of print] PubMed PMID: 29294275.

2) Fang, W.; Robinson, D. A.; Raimi, O. G.; Blair, D. E.; Harrison, J. R.; Lockhart, D. E.; Torrie, L. S.; Ruda, G. F.; Wyatt, P. G.; Gilbert, I. H.; van Aalten, D. M. N-myristoyltransferase is a cell wall target in aspergillus fumigatus. ACS Chem. Biol. 2015, 10, 1425−1434.