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Overview
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
Chemical Properties
| Molecular Formula | C12H12IN |
| Molecular Weight | 297.13 |
| CAS Numbers | 36913-39-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | I.c1ccc(cc1)-c1ccncc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019 Feb 5;509[2] 390-394.