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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $26.35 | Total: $131.75 |
| 1 | 10 | $22.32 | Total: $223.20 |
| 1 | 25 | $18.91 | Total: $472.75 |
| 1 | 50 | $16.12 | Total: $806.00 |
| 1 | 100 | $13.95 | Total: $1,395.00 |
Overview
APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.
Chemical Properties
| Molecular Formula | C22H14FN5 |
| Molecular Weight | 367.38 |
| CAS Numbers | 916151-99-0 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cc1[nH]c2ccc(F)cc2c1-c1nc2c([nH]1)c1cccnc1c1ncccc21 |
Storage and Handling
0C Short Term, -20C Long Term
References
Local A, et al. APTO-253 Stabilizes G-quadruplex DNA, Inhibits MYC Expression, and Induces DNA Damage in Acute Myeloid Leukemia Cells. Mol Cancer Ther. 2018 Jun;17[6] 1177-1186.