Categories
- PROTAC Linker
- Protein Control Ligand
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- Function Modulators
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $36.55 | Total: $182.75 |
| 1 | 10 | $30.96 | Total: $309.60 |
| 1 | 25 | $26.23 | Total: $655.75 |
| 1 | 50 | $22.36 | Total: $1,118.00 |
| 1 | 100 | $19.35 | Total: $1,935.00 |
Overview
McMMAF is a protective group-conjugated MMAF. MMAF is a potent tubulin polymerization inhibitor.It is a MMAF derivative having a Maleimidocaproyl linker (MC linker), which is ready to conjugate to antibody or other proteins or biopolymers. Mafodotin is a useful agent for make antibody drug conjugate (ADC) for targeted drug delivery.
Chemical Properties
| Molecular Formula | C49H76N6O11 |
| Molecular Weight | 925.16 |
| CAS Numbers | 863971-19-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(CCCCCN3C(=O)C=CC3=O)=O)C)[C@@H](C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H] |
Storage and Handling
0C Short Term, -20C Long Term
References
Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma target and linker-drug selection. Cancer Res. 2009 Mar 15;69[6] 2358-2364.