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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $23.80 | Total: $119.00 |
| 1 | 10 | $20.16 | Total: $201.60 |
| 1 | 25 | $17.08 | Total: $427.00 |
| 1 | 50 | $14.56 | Total: $728.00 |
| 1 | 100 | $12.60 | Total: $1,260.00 |
Overview
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 ?M (Cardiac muscle myosin), 9.1 ?M (Skeletal muscle myosin), and >100 ?M (Smooth muscle myosin II). It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 ?M. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 ?M.
Chemical Properties
| Molecular Formula | C19H17NO4 |
| Molecular Weight | 323.34 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1cccc(CN=C(C)c2c(O)c3ccccc3oc2=O)c1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Smith JD, et al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2023;247 115008.