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Overview
Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting ?-aminolevulinic acid synthetase activity through biochemical feedback.
Chemical Properties
| Molecular Formula | C34H32ClFeN4O4 |
| Molecular Weight | 651.94 |
| CAS Numbers | 16009-13-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | [Cl-].[Fe+3].Cc1c(CCC(O)=O)c2cc3[n-]c(cc4nc(cc5[n-]c(cc1n2)c(C=C)c5C)c(C=C)c4C)c(C)c3CCC(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Vanova K, et al. Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells. BMC Cancer. 2016 May 12;16 309.