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Overview
Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19 nM at pH 6.5.
Chemical Properties
| Molecular Formula | C21H20FN3O6S |
| Molecular Weight | 461.46 |
| CAS Numbers | 881681-01-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | OC(=O)C=CC(O)=O.CNCc1cc(-c2ccccc2F)n(c1)S(=O)(=O)c1cccnc1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Masaoka T, et al. Pathophysiology of Potassium-competitive Acid Blocker-refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test. J Neurogastroenterol Motil. 2018 Oct 1;24[4] 577-583.