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Overview
Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic activation. The drug was approved for use in the European Union by the European Commission on December 3, 2010, and by the US FDA on July 20, 2011. Its trade names are Brilinta (US), Brilique(EU) and Possia(EU).
Chemical Properties
| Molecular Formula | C23H28F2N6O4S |
| Molecular Weight | 522.57 |
| CAS Numbers | 274693-27-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(F)c(F)c2)c2nnn([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)c2n1 |
Storage and Handling
0C Short Term, -20C Long Term
References
VAN Giezen JJ, et al. J Thromb Haemost, 2009, 7[9], 1556-1565.