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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $100.30 | Total: $501.50 |
| 1 | 10 | $84.96 | Total: $849.60 |
| 1 | 25 | $71.98 | Total: $1,799.50 |
| 1 | 50 | $61.36 | Total: $3,068.00 |
| 1 | 100 | $53.10 | Total: $5,310.00 |
Overview
CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It exhibits significant activity against BRAF and NRAS mutant melanomas and demonstrates anticancer cell proliferative effects [1].
Chemical Properties
| Molecular Formula | C28H27N7O3S |
| Molecular Weight | 541.62 |
| CAS Numbers | 1163719-91-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N(C(NC1=C(SC)C=C(OC2=C3C(=NC=C2)NC(=O)C=N3)C=C1)=O)C=4N(N=C(C(C)(C)C)C4)C5=CC=CC=C5 |
Storage and Handling
0C Short Term, -20C Long Term
References
Girotti MR, et al. Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. Cancer Cell. 2015 Jan 12;27[1] 85-96.