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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $26.35 | Total: $131.75 |
| 1 | 10 | $22.32 | Total: $223.20 |
| 1 | 25 | $18.91 | Total: $472.75 |
| 1 | 50 | $16.12 | Total: $806.00 |
| 1 | 100 | $13.95 | Total: $1,395.00 |
Overview
BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases (IC50s: 0.4, 0.8 and 0.6 nM). BI-882370 also inhibits SRC family kinases.
Chemical Properties
| Molecular Formula | C28H33F2N7O2S |
| Molecular Weight | 569.67 |
| CAS Numbers | 1392429-79-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CCCS(=O)(=O)Nc1ccc(F)c(c1F)-n1cc(-c2cncnc2)c2nc(ccc12)N(C)C1CCN(CC)CC1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Waizenegger IC, et al. A Novel RAF Kinase Inhibitor with DFG-Out-Binding Mode High Efficacy in BRAF-Mutant Tumor Xenograft Models in the Absence of Normal Tissue Hyperproliferation. Mol Cancer Ther. 2016 Mar;15[3] 354-65.