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Overview
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine.
Chemical Properties
| Molecular Formula | C6H13NO2 |
| Molecular Weight | 131.17 |
| CAS Numbers | 319-78-8 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC[C@@H](C)[C@@H](N)C(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Rosenberg D, et, al. Neuronal D-serine and glycine release via the Asc-1 transporter regulates NMDA receptor-dependent synaptic activity. J Neurosci. 2013 Feb 20;33[8] 3533-44.