Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $288.15 | Total: $1,440.75 |
| 1 | 10 | $244.08 | Total: $2,440.80 |
| 1 | 25 | $206.79 | Total: $5,169.75 |
| 1 | 50 | $176.28 | Total: $8,814.00 |
| 1 | 100 | $152.55 | Total: $15,255.01 |
Overview
GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.
Chemical Properties
| Molecular Formula | C22H21F3N6 |
| Molecular Weight | 426.44 |
| CAS Numbers | 1003019-41-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@H]1CN(Cc2cn[nH]c2-c2ccc(cc2)C#N)CCN1c1ccc(cn1)C(F)(F)F |
Storage and Handling
0C Short Term, -20C Long Term
References
Miller AT, et al. Conversion of antigen-specific effectormemory T cells into Foxp3-expressing Treg cells by inhibition of CDK819. Sci Immunol. 2019 Oct 25;4[40]. pii eaaw2707.