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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $90.10 | Total: $450.50 |
| 1 | 10 | $76.32 | Total: $763.20 |
| 1 | 25 | $64.66 | Total: $1,616.50 |
| 1 | 50 | $55.12 | Total: $2,756.00 |
| 1 | 100 | $47.70 | Total: $4,770.00 |
Overview
Cyclosporin H (CsH), a specific inhibitor of FPR1, inhibited lung inflammation in the ALI models. CsH significantly attenuated MTDs or NFP-induced inflammatory lung injury and activation of MAPK and AKT pathways. Cyclosporin H is a viral transduction enhancer which increases lentiviral transduction up to 10-fold in human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). When combined with Rapamycin or Prostaglandin E2 Cyclosporin H displays an additive effect. Cyclosporin H lacks immunosuppressant activity of Cyclosporin A.
Chemical Properties
| Molecular Formula | C62H111N11O12 |
| Molecular Weight | 1202.61 |
| CAS Numbers | 83602-39-5 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC=CC[C@H](C)[C@H](O)C1N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)CCCNC1=O)C(C)C |
Storage and Handling
0C Short Term, -20C Long Term
References
Zhang X, et al. Mitochondrial peptides cause proinflammatory responses in the alveolar epithelium via FPR-1, MAPKs, and AKT a potential mechanism involved in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2018;315[5] L775-L786.